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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 286030: 2-deoxy-D-gluconate 3-dehydrogenase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-deoxy-D-gluconate 3-dehydrogenase. [EC: 1.1.1.125]
2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH.
    		 1146 A0A017IAF0 A0A017IAF0 A0A023V4G6 A0A023V4G6 A0A023Z2A9 A0A023Z2A9 A0A024KQ73 A0A024KQ73 A0A025CWU0 A0A025CWU0
    (1136 more...)
    2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase. [EC: 1.1.1.127]
    2-dehydro-3-deoxy-D-gluconate + NAD(+) = (4S)-4,6-dihydroxy-2,5- dioxohexanoate + NADH.
    • The enzyme from Pseudomonas acts equally well on NAD(+) or NADP(+), while those from Erwinia chrysanthemi and Escherichia coli are more specific for NAD(+).
    		 926 A0A023V4G6 A0A023V4G6 A0A023Z2A9 A0A023Z2A9 A0A024KQ73 A0A024KQ73 A0A025CWU0 A0A025CWU0 A0A026S0V9 A0A026S0V9
    (916 more...)
    Gluconate 5-dehydrogenase. [EC: 1.1.1.69]
    D-gluconate + NAD(P)(+) = 5-dehydro-D-gluconate + NAD(P)H.
      		 10 A0A0T8PWK4 A0A0T8PWK4 A0A1M7J8X8 A0A1M7J8X8 F5S1F6 F5S1F6 G8LKK6 G8LKK6 W0BR47 W0BR47
      3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
      (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
      • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
      		 2 F5RSH8 F5RSH8