The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 285744: 15-hydroxyprostaglandin dehydrogenase [NAD+]-like ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016404
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016404
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
|
4 | O08699 (/IDA) P15428 (/IDA) Q3T0C2 (/IDA) Q8VCC1 (/IDA) |
|
15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016404
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
|
2 | G1TBB5 (/TAS) P15428 (/TAS) |
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | P15428 (/IDA) |
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | Q8VCC1 (/ISO) |
|
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
|
1 | P15428 (/IDA) |
|
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
|
1 | Q8VCC1 (/ISO) |
|
15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016404
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
|
1 | Q8VCC1 (/ISO) |
|
15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016404
Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
|
1 | P15428 (/NAS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O08699 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P15428 (/TAS) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
1 | P15428 (/IDA) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
1 | Q8VCC1 (/ISO) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | P15428 (/IDA) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | Q8VCC1 (/ISO) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Parturition GO:0007567
The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Ovulation GO:0030728
The release of a mature ovum/oocyte from an ovary.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P15428 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8VCC1 (/ISS) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Thrombin-activated receptor signaling pathway GO:0070493
The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) P15428 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) Q8VCC1 (/ISS) |
|
Ductus arteriosus closure GO:0097070
The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.
|
9 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) P15428 (/ISS) P70684 (/ISS) Q3T0C2 (/ISS) Q8MJY8 (/ISS) |
|
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
|
3 | O08699 (/IDA) P15428 (/IDA) Q3T0C2 (/IDA) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | O08699 (/IEP) |
|
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
|
1 | Q8VCC1 (/ISO) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P15428 (/IDA) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8VCC1 (/ISO) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | P15428 (/IDA) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | O08699 (/IEP) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | Q8VCC1 (/ISO) |
|
Parturition GO:0007567
The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
|
1 | P15428 (/IDA) |
|
Parturition GO:0007567
The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
|
1 | Q8VCC1 (/ISO) |
|
Lipoxygenase pathway GO:0019372
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.
|
1 | P15428 (/TAS) |
|
Ovulation GO:0030728
The release of a mature ovum/oocyte from an ovary.
|
1 | Q8MJY8 (/IEP) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | O08699 (/IEP) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | O08699 (/IEP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | O08699 (/IDA) |
|
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
|
1 | O08699 (/IDA) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
1 | P15428 (/IDA) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
1 | Q8VCC1 (/ISO) |
|
Estrous cycle phase GO:0060206
The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur.
|
1 | Q3T0C2 (/IEP) |
|
Thrombin-activated receptor signaling pathway GO:0070493
The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
1 | O08699 (/IEP) |
|
Ductus arteriosus closure GO:0097070
The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.
|
1 | Q8VCC1 (/IMP) |
|
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
|
1 | O08699 (/IMP) |
|
Lipoxin metabolic process GO:2001300
The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid.
|
1 | P15428 (/TAS) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | A2T0Y1 (/ISS) D2HK00 (/ISS) E2QX67 (/ISS) F6U1R8 (/ISS) O08699 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | F6Q486 (/IDA) O08699 (/IDA) Q8MJY8 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | G1TBB5 (/TAS) P15428 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | O08699 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P15428 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8VCC1 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P15428 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8VCC1 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P15428 (/NAS) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q8VCC1 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P15428 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q8VCC1 (/ISO) |