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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 285055: D-lactate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-lactate dehydrogenase. [EC: 1.1.1.28]
(R)-lactate + NAD(+) = pyruvate + NADH.
    		 52 A0A077ULG1 A0A077VW77 A0A0D1I5H9 A0A0E1ALN1 A0A0E1VXH7 A0A0E1XBA9 A0A0E2MY96 A0A0H2XH62 A0A0H3KIW0 A0A0U1MER1
    (42 more...)
    4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
    4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
    • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
    • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
    • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
    • Cf. EC 1.1.1.399.
    		 9 A0A0E1V9P1 A0A0E1VXH7 A0A0E1XBA9 A0A0Z4YBP1 A0A1F1DBH8 A0A1J4FYW4 A0A1J4HE39 A0A1L1F1J3 Q6GDS2