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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 284148: Putative progesterone 5-beta-reductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-oxo-5-beta-steroid 4-dehydrogenase. [EC: 1.3.99.6]
A 3-oxo-5-beta-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
    		 86 A0A024D9W4 A0A024D9W4 A0A024D9Z7 A0A024D9Z7 A0A024DA00 A0A024DA00 A0A024DAK6 A0A024DAK6 A0A024DAY5 A0A024DAY5
    (76 more...)
    3-beta-hydroxy-Delta(5)-steroid dehydrogenase. [EC: 1.1.1.145]
    A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
    • Acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17- dione and on 3-beta-hydroxypregn-5-en-20-one to form progesterone.
    		 44 D6N9W8 D6N9W8 D6N9W9 D6N9W9 D6N9X0 D6N9X0 D6N9X1 D6N9X1 D6N9X2 D6N9X2
    (34 more...)
    Delta(4)-3-oxosteroid 5-beta-reductase. [EC: 1.3.1.3]
    (1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
    • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
    • The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
    		 36 A0A075M2G6 A0A075M2G6 A0A075M737 A0A075M737 A0A178V158 A0A178V158 D6NKI2 D6NKI2 D6P3J0 D6P3J0
    (26 more...)
    Iridoid synthase. [EC: 1.3.1.99]
    (6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).
    • Isolated from the plant Catharanthus roseus.
    • The reaction may involve cyclization via a Diels-Alder or Michael reaction.
    • Iridoids are involved in the biosynthesis of many indole alkaloids.
    • The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.
    		 2 K7WDL7 K7WDL7