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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 233001: Quinone oxidoreductase-like protein At1g23740, chl...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADPH:quinone reductase. [EC: 1.6.5.5]
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
  • Specific for NADPH.
  • Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates.
  • Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate.
  • The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2).
  • Abundant in the lens of the eye of some mammalian species.
 6 A0A0B2R4T4 A0A0B2R4T4 A0A0B2R4U7 A0A0B2R4U7 B9SHB0 B9SHB0
2-methylene-furan-3-one reductase. [EC: 1.3.1.105]
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NAD(P)(+) = 4-hydroxy-5-methyl-2- methylenefuran-3(2H)-one + NAD(P)H.
  • In the fruit-ripening process of strawberry (Fragaria x ananassa) the reaction is catalyzed in the reverse direction from that shown.
  • 4-hydroxy-2,5-dimethylfuran-3(2H)-one is one of the major aroma compounds in the fruits.
  • The enzyme has also been detected in tomato (Solanum lycopersicum) fruits.
  • NADPH is the preferred cofactor.
 4 K4BW79 K4BW79 Q84V25 Q84V25