View in Gene3D

CATH Superfamily 3.40.50.620

HUPs

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 89224: FAD synthetase, putative (AFU_orthologue AFUA_6G11...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
FAD synthetase. [EC: 2.7.7.2]
ATP + FMN = diphosphate + FAD.
  • Highly specific for ATP as phosphate donor.
  • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates.
  • While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26.
 130 A0A024VQH8 A0A024VQH8 A0A024WPG8 A0A024WPG8 A0A024X9G4 A0A024X9G4 A0A060RYL3 A0A060RYL3 A0A074T1D9 A0A074T1D9
(120 more...)
TRNA (guanine(37)-N(1))-methyltransferase. [EC: 2.1.1.228]
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
  • This enzyme is important for the maintenance of the correct reading frame during translation.
  • Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37.
  • Formerly EC 2.1.1.31.
 6 A0A195B8H3 A0A195B8H3 A0A195FV99 A0A195FV99 A0A1D2N2D3 A0A1D2N2D3
RNA helicase. [EC: 3.6.4.13]
ATP + H(2)O = ADP + phosphate.
  • RNA helicases utilize the energy from ATP hydrolysis to unwind RNA.
  • Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity.
  • Some helicases unwind DNA as well as RNA.
  • May be identical with EC 3.6.4.12 (DNA helicase).
 2 K1XZM7 K1XZM7
Phosphoadenylyl-sulfate reductase (thioredoxin). [EC: 1.8.4.8]
Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
  • Specific for PAPS.
  • The enzyme from Escherichia coli will use thioredoxins from other species.
  • Formerly EC 1.8.99.4.
 2 E0VLV1 E0VLV1