The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88713: Glutamate--tRNA ligase 2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutamate--tRNA ligase. [EC: 6.1.1.17]
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
    694 A0A011URY2 A0A011VAV4 A0A013XTB2 A0A024LRK7 A0A031HQE6 A0A031JM05 A0A031JVK2 A0A031M7Z6 A0A037UYB1 A0A037ZNI2
    (684 more...)
    Glutamate--tRNA(Gln) ligase. [EC: 6.1.1.24]
    ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx).
    • When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as EC 6.1.1.17.
    • It has, however, diminished discrimination, so that it can also form glutamate-tRNA(Gln).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
    • The ability of this enzyme to recognize both tRNA(Glu) and one of the tRNA(Gln) isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2- thiouridine).
    • The glutamyl-tRNA(Gln) is not used in protein synthesis until it is converted by EC 6.3.5.7 into glutaminyl-tRNA(Gln).
    32 A0A017HDG8 A0A017HEA6 A0A024K7R8 A0A060QEQ6 A0A060QFL8 A0A087PJR8 A0A094ZK79 A0A0A0HI52 A0A0A8K581 A0A0D0NQB4
    (22 more...)
    Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10]
    ATP + H(2)O = ADP + phosphate.
    • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
    • They comprise a number of heat-shock-cognate proteins.
    • They are also active in clathrin uncoating and in the oligomerization of actin.
    7 A0A0M2Y9D6 C0G6B0 C0RIZ2 C4IQT5 C4WJ13 D7H3G2 M5K204
    Glutamine--tRNA ligase. [EC: 6.1.1.18]
    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl- tRNA(Gln).
      1 A0A173KVN8
      Alanine--tRNA ligase. [EC: 6.1.1.7]
      ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
        1 U2WDK6