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CATH Superfamily 3.40.50.360

Flavodoxin domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12812: Flavodoxin

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

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EC Term Annotations Evidence
Nitrogenase (flavodoxin). [EC: 1.19.6.1]
4 reduced flavodoxin + N(2) + 16 ATP + 16 H(2)O = 4 oxidized flavodoxin + H(2) + 2 NH(3) + 16 ADP + 16 phosphate.
  • Composed of two components, dinitrogen reductase and dinitrogenase, that can be separated but are both required for nitrogenase activity.
  • Dinitrogen reductase is a [4Fe-4S] protein, which, at the expense of ATP, transfers electrons from a dedicated flavodoxin to dinitrogenase.
  • Dinitrogenase is a protein complex that contains either a molybdenum- iron cofactor, a vanadium-iron cofactor, or an iron-iron cofactor, that reduces dinitrogen in three succesive two-electron reductions from nitrogen to diimine to hydrazine to two molecules of ammonia.
  • The reduction is initiated by formation of hydrogen.
  • The enzyme can also reduce acetylene to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia.
  • In the absence of a suitable substrate, hydrogen is slowly formed.
  • Some enzymes utilize ferredoxin rather than flavodoxin as the electron donor (see EC 1.18.6.1).
  • Formerly EC 1.19.2.1.
 7 A0A0A7X4I5 A0A0H3BJL3 A0A1L7DGA5 F7XR08 H6KVJ8 O83895 R9UUA1