The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 634810: 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphat...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
16 A0A0A6YW89 (/ISO) A0A0A6YY64 (/ISO) A2AUP1 (/ISO) A2AUP3 (/ISO) A2AUP4 (/ISO) A2AUP5 (/ISO) A7UAK4 (/ISO) A7UAK5 (/ISO) A7UAK8 (/ISO) P70265 (/ISO)
(6 more)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
7 P26285 (/ISS) P70265 (/ISS) Q0KHQ6 (/ISS) Q5NVT1 (/ISS) Q9JJH5 (/ISS) Q9VWH7 (/ISS) X2JED9 (/ISS)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
6 P07953 (/ISS) P49872 (/ISS) P70266 (/ISS) Q0KHQ6 (/ISS) Q9VWH7 (/ISS) X2JED9 (/ISS)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
5 P07953 (/IDA) P16118 (/IDA) P25114 (/IDA) P70265 (/IDA) Q9JJH5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O60825 (/IPI) P16118 (/IPI) P32604 (/IPI) P40433 (/IPI) Q9N590 (/IPI)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
4 O60825 (/EXP) P16118 (/EXP) Q16875 (/EXP) Q16877 (/EXP)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
4 O60825 (/IDA) P07953 (/IDA) P25114 (/IDA) P40433 (/IDA)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
4 O60825 (/TAS) P16118 (/TAS) Q91348 (/TAS) Q9JJH5 (/TAS)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
4 O35552 (/TAS) P16118 (/TAS) Q91348 (/TAS) Q9JJH5 (/TAS)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
3 O60352 (/NAS) Q16875 (/NAS) Q16877 (/NAS)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
2 P70266 (/ISO) Q9URZ7 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
2 P07953 (/IPI) Q9JJH5 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P07953 (/IPI) P16118 (/IPI)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
1 P40433 (/IMP)
6-phosphofructo-2-kinase activity GO:0003873
Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
1 C8VF10 (/RCA)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
1 P32604 (/IMP)
Fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.
1 O60352 (/NAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P07953 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O60825 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P70265 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P07953 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P70266 (/ISO)
Fructose-6-phosphate binding GO:0070095
Interacting selectively and non-covalently with fructose 6-phosphate.
1 P07953 (/IDA)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
7 P26285 (/ISS) P70265 (/ISS) Q0KHQ6 (/ISS) Q5NVT1 (/ISS) Q9JJH5 (/ISS) Q9VWH7 (/ISS) X2JED9 (/ISS)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
5 O60825 (/TAS) P07953 (/TAS) P16118 (/TAS) Q16875 (/TAS) Q16877 (/TAS)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
3 O35552 (/IDA) P16118 (/IDA) Q9MB58 (/IDA)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
3 P70266 (/ISO) Q8TFH0 (/ISO) Q9UTE1 (/ISO)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
3 P07953 (/ISS) P49872 (/ISS) P70266 (/ISS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
3 P07953 (/TAS) P16118 (/TAS) Q91348 (/TAS)
Carbohydrate phosphorylation GO:0046835
The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
3 Q0KHQ6 (/ISS) Q9VWH7 (/ISS) X2JED9 (/ISS)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
2 P07953 (/TAS) Q9JJH5 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
2 P16118 (/TAS) Q91348 (/TAS)
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
1 Q9MB58 (/IDA)
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
1 O60825 (/TAS)
Fructose 6-phosphate metabolic process GO:0006002
The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
1 Q9MB58 (/IDA)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
1 Q9UTK9 (/IC)
Fructose 2,6-bisphosphate metabolic process GO:0006003
The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
1 P40433 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 P32604 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 Q9URZ7 (/ISO)
Glucose catabolic process GO:0006007
The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.
1 Q9JJH5 (/IDA)
Lactate metabolic process GO:0006089
The chemical reactions and pathways involving lactate, the anion of lactic acid.
1 Q9JJH5 (/IDA)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 Q9JJH5 (/IDA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 O60825 (/IDA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 P70265 (/ISO)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
1 Q8TFH0 (/IC)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
1 O35552 (/TAS)
Energy reserve metabolic process GO:0006112
The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
1 P07953 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 O35552 (/IEP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q9JJH5 (/IDA)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P07953 (/IEP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q9JJH5 (/IDA)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P07953 (/IEP)
Positive regulation of glucokinase activity GO:0033133
Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
1 Q9JJH5 (/IDA)
Positive regulation of glucokinase activity GO:0033133
Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
1 P07953 (/IMP)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
1 P07953 (/IEP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P07953 (/TAS)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 P07953 (/IEP)
Regulation of carbon utilization GO:0043609
Any process that modulates the frequency, rate, or extent of carbon utilization.
1 Q9MB58 (/IMP)
Carbohydrate phosphorylation GO:0046835
The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
1 P07953 (/IDA)
Carbohydrate phosphorylation GO:0046835
The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
1 C8VF10 (/RCA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P07953 (/IEP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P07953 (/IEP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
11 A0A0A6YW89 (/ISO) A0A0A6YY64 (/ISO) A2AUP1 (/ISO) A2AUP3 (/ISO) A2AUP4 (/ISO) A2AUP5 (/ISO) A7UAK4 (/ISO) A7UAK5 (/ISO) A7UAK8 (/ISO) Q3U3S6 (/ISO)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O60825 (/TAS) P07953 (/TAS) P16118 (/TAS) Q16875 (/TAS) Q16877 (/TAS) Q91348 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 F2Z2I2 (/IDA) Q16875 (/IDA) Q5VX20 (/IDA) Q5W015 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8TFH0 (/ISO) Q9UTE1 (/ISO) Q9UTK9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q0KHQ6 (/ISS) Q9VWH7 (/ISS) X2JED9 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9MB58 (/IDA) Q9UTE1 (/IDA) Q9UTK9 (/IDA)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex GO:0043540
A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
3 P07953 (/ISS) P49872 (/ISS) P70266 (/ISS)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex GO:0043540
A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
2 P07953 (/IDA) P16118 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UTE1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P40433 (/IC)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JJH5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9URZ7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9MB58 (/IDA)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex GO:0043540
A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
1 P70266 (/ISO)