The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 631791: ATP-dependent RNA helicase DDX1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
Nuclease activity GO:0004518
Catalysis of the hydrolysis of ester linkages within nucleic acids.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
ATP-dependent helicase activity GO:0008026
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
DNA/RNA helicase activity GO:0033677
Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q91VR5 (/IPI) Q92499 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q92499 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q91VR5 (/ISO) |
|
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
1 | Q92499 (/IDA) |
|
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
1 | Q91VR5 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q92499 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q91VR5 (/ISO) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix.
|
1 | Q92499 (/TAS) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
1 | Q91VR5 (/IDA) |
|
Helicase activity GO:0004386
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | Q9VNV3 (/ISS) |
|
Nuclease activity GO:0004518
Catalysis of the hydrolysis of ester linkages within nucleic acids.
|
1 | Q92499 (/IDA) |
|
Nuclease activity GO:0004518
Catalysis of the hydrolysis of ester linkages within nucleic acids.
|
1 | Q91VR5 (/ISO) |
|
ATP-dependent helicase activity GO:0008026
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | Q92499 (/IDA) |
|
ATP-dependent helicase activity GO:0008026
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | Q91VR5 (/ISO) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
1 | Q92499 (/IDA) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
1 | Q91VR5 (/ISO) |
|
DNA/RNA helicase activity GO:0033677
Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
|
1 | Q92499 (/IDA) |
|
DNA/RNA helicase activity GO:0033677
Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
|
1 | Q91VR5 (/ISO) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
8 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) |
|
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
|
1 | Q92499 (/NAS) |
|
Embryonic development via the syncytial blastoderm GO:0001700
The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.
|
1 | Q9VNV3 (/IEP) |
|
Embryonic development via the syncytial blastoderm GO:0001700
The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.
|
1 | Q24731 (/ISS) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q92499 (/IDA) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q91VR5 (/ISO) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
1 | Q92499 (/IMP) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
1 | Q91VR5 (/ISO) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
1 | Q92499 (/TAS) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | Q92499 (/NAS) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | Q92499 (/IEP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q9VNV3 (/IMP) |
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | Q91VR5 (/IMP) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
1 | Q92499 (/IDA) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
1 | Q91VR5 (/ISO) |
|
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
|
1 | Q9VNV3 (/ISS) |
|
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
1 | Q91VR5 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
1 | Q9VNV3 (/IMP) |
|
Nucleic acid phosphodiester bond hydrolysis GO:0090305
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
|
1 | Q92499 (/IDA) |
|
Nucleic acid phosphodiester bond hydrolysis GO:0090305
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
|
1 | Q91VR5 (/ISO) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
1 | Q92499 (/IMP) |
|
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
|
1 | Q91VR5 (/ISO) |
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q24731 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) Q9VNV3 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) |
|
TRNA-splicing ligase complex GO:0072669
A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.
|
8 | A2VD92 (/ISS) Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q5XH91 (/ISS) Q641Y8 (/ISS) Q90WU3 (/ISS) Q91VR5 (/ISS) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
5 | Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q641Y8 (/ISS) Q91VR5 (/ISS) |
|
Cleavage body GO:0071920
A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
|
5 | Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q641Y8 (/ISS) Q91VR5 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | A0A087X2G1 (/IDA) A3RJH1 (/IDA) F1T0B3 (/IDA) Q92499 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A0A087X2G1 (/IDA) A3RJH1 (/IDA) F1T0B3 (/IDA) Q92499 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
2 | Q91VR5 (/IDA) Q92499 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q92499 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q91VR5 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q91VR5 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q92499 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q92499 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q91VR5 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q91VR5 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q91VR5 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q92499 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q91VR5 (/ISO) |
|
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
|
1 | Q92499 (/IDA) |
|
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
|
1 | Q91VR5 (/ISO) |
|
Cleavage body GO:0071920
A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
|
1 | Q92499 (/IDA) |
|
Cleavage body GO:0071920
A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
|
1 | Q91VR5 (/ISO) |
|
TRNA-splicing ligase complex GO:0072669
A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.
|
1 | Q92499 (/IDA) |
|
TRNA-splicing ligase complex GO:0072669
A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.
|
1 | Q91VR5 (/ISO) |