The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 631150: Axonemal dynein heavy chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
7 D3YYQ8 (/IC) E9Q0B6 (/IC) E9Q3H7 (/IC) E9Q8T7 (/IC) F7ABZ6 (/IC) O08828 (/IC) Q8WXX0 (/IC)
Dynein light chain binding GO:0045503
Interacting selectively and non-covalently with a light chain of the dynein complex.
5 A8I3X6 (/IPI) A8I5C3 (/IPI) A8ISA6 (/IPI) A8IV22 (/IPI) Q4AC22 (/IPI)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
4 Q7KVA7 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
4 Q7KVA7 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
2 Q9MBF8 (/IDA) Q9SMH3 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P36022 (/IDA) Q4AC22 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 Q9MBF8 (/IDA) Q9SMH3 (/IDA)
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
2 A8JDH8 (/IDA) P36022 (/IDA)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
1 Q8IBG1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P36022 (/IPI)
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
1 P36022 (/IMP)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
5 Q7KVA7 (/ISS) Q8IBG1 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
5 E9Q8T7 (/IMP) O08828 (/IMP) Q4AC22 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
4 D3YYQ8 (/IC) E9Q0B6 (/IC) E9Q3H7 (/IC) F7ABZ6 (/IC)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
4 Q7KVA7 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
4 Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
3 E9Q8T7 (/IMP) O08828 (/IMP) Q9P2D7 (/IMP)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
3 Q4AC22 (/IGI) Q9MBF8 (/IGI) Q9SMH3 (/IGI)
Epithelial cilium movement GO:0003351
The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid.
2 E9Q8T7 (/IMP) O08828 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 E9Q8T7 (/ISO) O08828 (/ISO)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
2 E9Q8T7 (/ISO) O08828 (/ISO)
Epithelial cilium movement involved in determination of left/right asymmetry GO:0060287
The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves.
2 E9QH47 (/IMP) F1Q6J7 (/IMP)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
2 E9QH47 (/IGI) F1Q6J7 (/IGI)
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
2 E9QH47 (/IMP) F1Q6J7 (/IMP)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
1 P36022 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
1 P36022 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
1 P36022 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
1 Q8WXX0 (/IMP)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
1 Q57YC6 (/TAS)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 Q57YC6 (/TAS)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 F1Q8L1 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q9VJC6 (/IMP)
Retrograde axonal transport GO:0008090
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
1 Q7KVA7 (/IMP)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
1 Q9VZ77 (/IMP)
Nuclear migration along microtubule GO:0030473
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
1 P36022 (/IGI)
Nuclear migration along microtubule GO:0030473
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.
1 P36022 (/IMP)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q9P2D7 (/IDA)
Establishment of mitotic spindle localization GO:0040001
The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.
1 P36022 (/IMP)
Sperm competition GO:0046692
Any process that contributes to the success of sperm fertilization in multiply-mated females.
1 Q9VZ77 (/IMP)
Determination of liver left/right asymmetry GO:0071910
Determination of the asymmetric location of the liver with respect to the left and right halves of the organism.
1 F1Q8L1 (/IMP)
Minus-end-directed vesicle transport along microtubule GO:0072382
The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.
1 Q57YC6 (/TAS)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
10 D3YYQ8 (/ISM) E9Q0B6 (/ISM) E9Q0T8 (/ISM) E9Q3H7 (/ISM) E9Q8T7 (/ISM) F7ABZ6 (/ISM) O08828 (/ISM) P0C6F1 (/ISM) Q3V0Q1 (/ISM) Q8BW94 (/ISM)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 A8I3X6 (/IMP) A8IV22 (/IMP) Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
5 A0A087WR13 (/ISO) E9Q0T8 (/ISO) E9Q8T7 (/ISO) L7N1Y0 (/ISO) O08828 (/ISO)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
4 Q7KVA7 (/ISS) Q8IBG1 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
4 Q4AC22 (/IDA) Q9MBF8 (/IDA) Q9P2D7 (/IDA) Q9SMH3 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
4 Q7KVA7 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A0A087WR13 (/ISO) E9Q0T8 (/ISO) L7N1Y0 (/ISO)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
3 E9Q8T7 (/IDA) O08828 (/IDA) Q9P2D7 (/IDA)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
2 E9Q8T7 (/ISO) O08828 (/ISO)
Astral microtubule GO:0000235
Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
1 P36022 (/IDA)
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
1 P36022 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WXX0 (/IDA)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
1 P36022 (/IPI)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
1 P36022 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 Q8WXX0 (/IDA)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 E9Q0T8 (/ISO)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q9MBF8 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 P36022 (/IDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
1 Q9VZ77 (/ISS)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 P0C6F1 (/IDA)