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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 630886: Cob(I)yrinic acid a,c-diamide adenosyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cob(I)yrinic acid a,c-diamide adenosyltransferase. [EC: 2.5.1.17]
(1) ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. (2) ATP + cobinamide = triphosphate + adenosylcobinamide.
  • The corrinoid adenosylation pathway comprises three steps: (1) Reduction of Co(III) to Co(II) by a one-electron transfer; this can be carried out by EC 1.16.1.3, or non-enzymically in the presence of dihydroflavin nucleotides. (2) Co(II) is reduced to Co(I) in a second single-electron transfer by EC 1.16.1.4. (3) The Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP to leave the cobalt atom in a Co(III) state (EC 2.5.1.17).
  • The enzyme responsible for the adenosylation reaction is the product of the gene cobO in the aerobic bacterium Pseudomonas denitrificans and of the gene cobA in the anaerobic bacterium Salmonella typhimurium.
  • In P.denitrificans, the enzyme shows specificity for cobyrinic acid a,c-diamide and the corrinoids that occur later in the biosynthetic pathway whereas CobA seems to have broader specificity.
  • While CobA has a preference for ATP and Mn(2+), it is able to transfer a variety of nucleosides to the cobalt, including CTP, UTP and GTP, in decreasing order of preference and to use Mg(2+) instead of Mn(2+).
 1395 A0A010S429 A0A011T8U9 A0A014M6B2 A0A017HGC7 A0A017HJL1 A0A017IIF1 A0A021X5Y6 A0A023L7Z9 A0A023VAA2 A0A023VD30
(1385 more...)
Tartronate O-hydroxycinnamoyltransferase. [EC: 2.3.1.106]
Sinapoyl-CoA + 2-hydroxymalonate = CoA + sinapoyltartronate.
  • 4-coumaroyl-CoA (4-hydroxycinnamoyl-CoA), caffeoyl-CoA (3,4- dihydroxycinnamoyl-CoA) and feruloyl-CoA (4-hydroxy-3- methoxycinnamoyl-CoA) can also act as donors for the enzyme from the mung bean (Vigna radiata).
 18 A0A0E1X5G7 A0A0F6ARA6 A0A0M1WB14 A0A0M2Y6G9 A0A1L5N8Z4 A9M5W7 B0CHA0 C0G736 C0RJR7 C4IS00
(8 more...)