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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 627667: Replication factor C subunit

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed DNA polymerase. [EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a primer which may be DNA or RNA.
  • See also EC 2.7.7.49.
 19 A0A074TPD6 A0A086JI13 A0A086KIC3 A0A086M0E2 A0A086Q4R1 A0A0B2RUK7 A0A0D2MDH4 A0A125YUA4 A0A125YUA5 A0A139XW65
(9 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 3 A0A060TE21 A0A0L1HJS4 A0A0P4U3B1
Cytochrome-c oxidase. [EC: 1.9.3.1]
4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
  • The reduction of O(2) to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
  • Several bacteria appear to contain analogous oxidases.
 1 A0A0R0KJP6
Chitosanase. [EC: 3.2.1.132]
Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chitosan.
  • A whole spectrum of chitosanases are now known that can hydrolyze various types of links in chitosan.
  • The only constant property is the endohydrolysis of GlcN-GlcN links, which is common to all known chitosanases.
  • One known chitosanase is limited to this link recognition, while the majority can also recognize GlcN-GlcNAc links or GlcNAc-GlcN links but not both.
  • They also do not recognize GlcNAc-GlcNAc links in partly acetylated chitosan.
 1 A0A0U1LYT9