The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 627173: Mitochondrial DNA helicase Twinkle
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
20 |
A5D7A7 (/ISS)
B0XE78 (/ISS)
B3MP19 (/ISS)
B3N8J2 (/ISS)
B4HWB5 (/ISS)
B4JE32 (/ISS)
B4KJD8 (/ISS)
B4LRC5 (/ISS)
B4MTK6 (/ISS)
B4NYN0 (/ISS)
(10 more) |
|
5'-3' DNA helicase activity GO:0043139
Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.
|
20 |
A5D7A7 (/ISS)
B0XE78 (/ISS)
B3MP19 (/ISS)
B3N8J2 (/ISS)
B4HWB5 (/ISS)
B4JE32 (/ISS)
B4KJD8 (/ISS)
B4LRC5 (/ISS)
B4MTK6 (/ISS)
B4NYN0 (/ISS)
(10 more) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
|
2 | Q8CIW5 (/IDA) Q8ILY1 (/IDA) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
2 | Q96RR1 (/IDA) Q9VL76 (/IDA) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
1 | Q96RR1 (/IPI) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
1 | Q8CIW5 (/ISO) |
|
DNA helicase activity GO:0003678
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
|
1 | Q8CIW5 (/ISA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
1 | Q9VL76 (/IDA) |
|
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
1 | Q8CIW5 (/ISO) |
|
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
|
1 | Q8ILY1 (/IDA) |
|
DNA primase activity GO:0003896
Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
|
1 | Q8ILY1 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8ILY1 (/IPI) |
|
3'-5' exonuclease activity GO:0008408
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
|
1 | Q8ILY1 (/IDA) |
|
5'-3' DNA helicase activity GO:0043139
Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.
|
1 | Q96RR1 (/IDA) |
|
5'-3' DNA helicase activity GO:0043139
Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.
|
1 | Q8CIW5 (/ISO) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | Q9VL76 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
|
19 |
A5D7A7 (/ISS)
B0XE78 (/ISS)
B3MP19 (/ISS)
B3N8J2 (/ISS)
B4HWB5 (/ISS)
B4JE32 (/ISS)
B4KJD8 (/ISS)
B4LRC5 (/ISS)
B4MTK6 (/ISS)
B4NYN0 (/ISS)
(9 more) |
|
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
|
2 | Q8CIW5 (/IMP) Q96RR1 (/IMP) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
2 | Q96RR1 (/IDA) Q9VL76 (/IDA) |
|
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
|
1 | Q9VL76 (/IMP) |
|
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
|
1 | Q8CIW5 (/ISO) |
|
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
|
1 | Q96RR1 (/NAS) |
|
DNA unwinding involved in DNA replication GO:0006268
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
|
1 | Q8CIW5 (/IDA) |
|
Transcription from mitochondrial promoter GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
|
1 | Q96RR1 (/IMP) |
|
Transcription from mitochondrial promoter GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
|
1 | Q8CIW5 (/ISO) |
|
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
1 | Q96RR1 (/TAS) |
|
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
|
1 | Q96RR1 (/IDA) |
|
Protein hexamerization GO:0034214
The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.
|
1 | Q8CIW5 (/ISO) |
|
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
1 | Q8CIW5 (/ISO) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | D3ZA68 (/IEP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
|
20 |
A5D7A7 (/ISS)
B0XE78 (/ISS)
B3MP19 (/ISS)
B3N8J2 (/ISS)
B4HWB5 (/ISS)
B4JE32 (/ISS)
B4KJD8 (/ISS)
B4LRC5 (/ISS)
B4MTK6 (/ISS)
B4NYN0 (/ISS)
(10 more) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | D3ZA68 (/IDA) Q8CIW5 (/IDA) Q9VL76 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | Q96RR1 (/TAS) |
|
Apicoplast GO:0020011
The plastid organelle found in apicomplexans.
|
1 | Q8ILY1 (/IDA) |
|
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
|
1 | Q96RR1 (/IDA) |
|
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
|
1 | Q8CIW5 (/ISO) |