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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 624835: ABC transporter ATP-binding component

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Heme-transporting ATPase. [EC: 3.6.3.41]
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
  • An enzyme found in Gram-negative bacteria that exports heme.
 431 A0A009FWQ0 A0A009GY57 A0A009H2J8 A0A009H8S9 A0A009I9L4 A0A009JBX1 A0A009JZN7 A0A009KPA2 A0A009MJB1 A0A009PJU1
(421 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 34 A0A085AC33 A0A085G2D3 A0A085GPT0 A0A085H3F1 A0A085H6V0 A0A085HGW4 A0A085I3W3 A0A085JJD2 A0A085UBL1 A0A0A6W5U5
(24 more...)
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 27 A0A0C9LH95 A0A0H3KGI4 A0A0P0R7J8 A0A0U5EY67 A0A142YX97 A0A1A7C3Z5 A0A1B1NLN1 A0A1B4TU51 A0A1C7FB45 A0A1D7ZEE6
(17 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 24 A0A085AC33 A0A085G2D3 A0A085GPT0 A0A085H3F1 A0A085H6V0 A0A085HGW4 A0A085I3W3 A0A085JJD2 A0A0B9AMF0 A0A0C5WDG7
(14 more...)
Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
  • A bacterial enzyme that imports ferric cations.
 2 A0A1J0NSF3 I2B162
Molybdate-transporting ATPase. [EC: 3.6.3.29]
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
  • A bacterial enzyme that imports molybdate anions.
 2 A0A0E2Z1J0 Q3JAI7
Phosphate-transporting ATPase. [EC: 3.6.3.27]
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
  • A bacterial enzyme that imports phosphate anions.
 2 H6SPY0 Q2RU68
Shikimate kinase. [EC: 2.7.1.71]
ATP + shikimate = ADP + shikimate 3-phosphate.
    		 1 U2EIZ2
    Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
    ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
    • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
    • Several distinct enzymes may be present in a single eukaryotic cell.
    • Many of them transport glutathione conjugates with drugs.
    • Some also show some 'flippase' (EC 3.6.3.1) activity.
    • Formerly EC 3.6.3.45.
    		 1 D5V8N5
    Monosaccharide-transporting ATPase. [EC: 3.6.3.17]
    ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
    • Family of bacterial enzymes importing ribose, xylose, arabinose, galactose and methylgalactoside.
    		 1 A0A1A0DF03