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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 624808: ATP-binding Cassette (ABC) Superfamily

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphonate-transporting ATPase. [EC: 3.6.3.28]
ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In).
  • A bacterial enzyme that imports phosphonate and organophosphate anions.
 19 B9RFG3 B9RGL9 B9RJZ4 B9RJZ6 B9RJZ7 B9RP91 B9RQF0 B9RQF1 B9RQF2 B9RZZ4
(9 more...)
Heme-transporting ATPase. [EC: 3.6.3.41]
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
  • An enzyme found in Gram-negative bacteria that exports heme.
 4 B9RJZ5 B9RQE9 B9SMW1 B9STK8
Polyamine-transporting ATPase. [EC: 3.6.3.31]
ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
  • A bacterial enzyme that imports putrescine and spermidine.
 2 B9RJZ6 B9SMW0
Molybdate-transporting ATPase. [EC: 3.6.3.29]
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
  • A bacterial enzyme that imports molybdate anions.
 2 A0A0B2P9I1 A0A0B2R8A5
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 1 B9RJZ3