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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 623897: V-type ATP synthase alpha chain

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
H(+)-transporting two-sector ATPase. [EC: 3.6.3.14]
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
  • A multisubunit non-phosphorylated ATPase that is involved in the transport of ions.
  • Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)).
  • The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases.
  • All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits.
  • Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis.
  • This movement is driven by the H(+) electrochemical potential gradient.
  • The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP.
  • Formerly EC 3.6.1.34.
 2720 A0A010NJU8 A0A010NUS6 A0A010ZZT8 A0A011SJJ5 A0A011VUT7 A0A015P1J7 A0A015RZ53 A0A015SCD9 A0A015SNV3 A0A015TI93
(2710 more...)
Sodium-transporting two-sector ATPase. [EC: 3.6.3.15]
ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).
  • A multisubunit non-phosphorylated ATPase that is involved in the transport of ions.
  • An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14.
 30 A0A086JGQ4 A0A086JKN7 A0A086L1B5 A0A086M7V7 A0A086PK92 A0A086PWZ5 A0A0E2HZ74 A0A0E9EQ49 A0A0E9F6X9 A0A0E9G1V0
(20 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 5 A0A170XL21 A7L4W1 G8HI69 G8HI88 Q946X7
Proton-exporting ATPase. [EC: 3.6.3.6]
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • Generates an electrochemical potential gradient of protons across the plasma membrane.
  • Formerly EC 3.6.1.35.
 3 A5AAF1 B6HJ23 G3Y1B9
Transferred entry: 3.6.3.14. [EC: 3.6.1.34]
    		2 Q9AVU8 Q9SM51
    Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
    NTP + H(2)O = NDP + phosphate.
    • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
    • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
    • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
    		 1 A0A170XL21
    Transferred entry: 3.6.3.6. [EC: 3.6.1.35]
      		1 P92128
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