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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 623439: EH domain-containing protein 1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Small monomeric GTPase. [EC: 3.6.5.2]
GTP + H(2)O = GDP + phosphate.
  • A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of EC 3.6.1.46.
  • Involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
  • Formerly EC 3.6.1.47.
 3 A0A178VAZ5 B3LF48 Q94CF0
RNA-directed RNA polymerase. [EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • See also EC 2.7.7.6.
 2 B0E7A5 B0EAG9
Phospholipase A(2). [EC: 3.1.1.4]
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
  • Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
 1 T0ME74
Thymidylate synthase. [EC: 2.1.1.45]
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
    		 1 Q5DG45