The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 622114: Genome polyprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 B1PVV8 (/IPI) F2X8A1 (/IPI) P19711 (/IPI) P19712 (/IPI) P21530 (/IPI) Q5U8X5 (/IPI) Q68871 (/IPI) Q96662 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P19711 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P19711 (/IDA)
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
1 P19711 (/IDA)
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
1 P19711 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Viral release from host cell GO:0019076
The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane.
1 P21530 (/IMP)
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
1 P21530 (/IDA)
Regulation of intermediate filament polymerization GO:0030839
Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament.
1 P21530 (/IMP)
Negative regulation of interferon-beta production GO:0032688
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
1 P19712 (/IDA)
Suppression by virus of host type I interferon production GO:0039501
Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P19712 (/IDA)
Suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process GO:0039551
Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome.
1 P19712 (/IDA)
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
1 P19711 (/IDA)
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
1 P19712 (/IDA)
Regulation of membrane tubulation GO:1903525
Any process that modulates the frequency, rate or extent of membrane tubulation.
1 P21530 (/IMP)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
1 P19712 (/IMP)
Negative regulation by symbiont of host protein levels GO:1990214
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P19712 (/IDA)
Negative regulation by symbiont of host protein levels GO:1990214
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P19712 (/IMP)
Positive regulation by symbiont of host protein levels GO:1990219
Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P19712 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Host cell cytoplasm GO:0030430
The cytoplasm of a host cell.
2 P19711 (/IDA) P19712 (/IDA)
Host cell nucleus GO:0042025
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 P19711 (/IDA) P19712 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 P19711 (/IDA)
Host cell mitochondrion GO:0033650
A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
1 P19711 (/IDA)
Host cell cytoplasmic vesicle GO:0044161
A vesicle formed of membrane or protein, found in the cytoplasm of a host cell.
1 P19711 (/IDA)
Host cell endoplasmic reticulum GO:0044165
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P19712 (/IDA)
Host cell Golgi apparatus GO:0044177
A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
1 P19711 (/IDA)
Integral to membrane of host cell GO:0044385
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell.
1 P19711 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
1 P19711 (/IDA)