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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 363618: Aerobic cobaltochelatase subunit CobS

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cobaltochelatase. [EC: 6.6.1.2]
ATP + hydrogenobyrinic acid a,c-diamide + Co(2+) + H(2)O = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H(2).
  • This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP- dependent.
  • It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST.
  • Hydrogenobyrinic acid is a very poor substrate.
  • ATP can be replaced by dATP or CTP but the reaction proceeds more slowly.
  • CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide.
  • The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding.
  • Once the Co(2+) is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I); this step is carried out by EC 1.16.8.1.
 142 A0A011TIG2 A0A021XG70 A0A060I5Q2 A0A072BVQ8 A0A083ZJX6 A0A084U7I6 A0A089P1S2 A0A090E7R6 A0A090E9A7 A0A090F3B4
(132 more...)
Quinate dehydrogenase (quinone). [EC: 1.1.5.8]
Quinate + quinone = 3-dehydroquinate + quinol.
  • The enzyme is membrane-bound.
  • Does not use NAD(P)(+) as acceptor.
  • Formerly EC 1.1.99.25.
 7 A0A0E1X9X7 C0G346 C4ITL4 C4WJZ9 D0P9M0 D1CUC8 Q8YJN3