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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 208222: Monofunctional C1-tetrahydrofolate synthase, mitoc...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Formate--tetrahydrofolate ligase. [EC: 6.3.4.3]
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
  • In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
 17 A0A136KZF0 A0A1F8KGL5 A0A1F8QGM2 A0A1J4ZW45 B9T077 B9T079 E0VA04 I0I5C6 P11586 P27653
(7 more...)
Methylenetetrahydrofolate dehydrogenase (NADP(+)). [EC: 1.5.1.5]
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
    		 9 A0A061HZ51 A0A0B2QZH4 A0A0B2RSC0 E0VA04 G3H4Z5 P11586 P27653 Q5R8P0 Q922D8
    Methenyltetrahydrofolate cyclohydrolase. [EC: 3.5.4.9]
    5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
      		 6 A0A0B2QZH4 A0A0B2RSC0 P11586 P27653 Q5R8P0 Q922D8