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CATH Superfamily 3.40.50.261

Succinyl-CoA synthetase domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Succinyl-CoA synthetase domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4928: Acetyl CoA synthetase, putative

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetate--CoA ligase (ADP-forming). [EC: 6.2.1.13]
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA.
  • Also acts on propanoate and, very slowly, on butanoate.
 65 A0A027TYL6 A0A028ASA8 A0A028E2Y3 A0A029HNU7 A0A029IMP9 A0A060VAI0 A0A068ZCD9 A0A090NGR6 A0A0A0FAS3 A0A0A8UFQ4
(55 more...)
Succinate--CoA ligase (ADP-forming). [EC: 6.2.1.5]
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
    		 35 A0A024V113 A0A024VJX2 A0A024VYC9 A0A024WJN5 A0A060RZY4 A0A077TLW3 A0A077X8H6 A0A078KGW4 A0A0L1IBN4 A0A0L7K636
    (25 more...)
    Long-chain-fatty-acid--CoA ligase. [EC: 6.2.1.3]
    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
    • Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.
    • The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
    		 1 F4N4K6
    Mycothiol synthase. [EC: 2.3.1.189]
    Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.
    • This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium.
    • The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs).
    • The enzyme has been purified from Mycobacterium tuberculosis H37Rv.
    • Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.
    		 1 A0A0B5FHC2