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CATH Superfamily 3.40.50.2300

Response regulator

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 152291: Phosphodiesterase 8, isoform A

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3',5'-cyclic-nucleotide phosphodiesterase. [EC: 3.1.4.17]
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
  • Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
 4 A0A0J9U9F1 B3MFI3 B4NMM0 Q28ZF2
3',5'-cyclic-AMP phosphodiesterase. [EC: 3.1.4.53]
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
  • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
  • Formerly EC 3.1.4.n1.
 3 E9Q4S1 O95263 Q6NNF2