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CATH Superfamily 3.40.50.2300

Response regulator

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 151864: Multi-sensor hybrid histidine kinase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
 3426 A0A009H1T2 A0A009HQ27 A0A009JSP1 A0A009K593 A0A009KJT3 A0A009SHH0 A0A009ZHG4 A0A010PEM5 A0A010RSW4 A0A011ME78
(3416 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 3 A0A1E3L191 J7J0W1 Q54Q69
Protein-glutamate methylesterase. [EC: 3.1.1.61]
Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol.
  • Hydrolyzes the products of EC 2.1.1.77, EC 2.1.1.78, EC 2.1.1.80 and EC 2.1.1.100.
 3 A0A167YIS2 A0A1J4SPZ2 U2BI55
Protein-histidine pros-kinase. [EC: 2.7.13.1]
ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine.
  • A number of histones can act as acceptor.
  • Formerly EC 2.7.3.11.
 2 A1K8N7 C3KKH3
Protein-glutamate O-methyltransferase. [EC: 2.1.1.80]
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
  • Forms ester groups with L-glutamate residues in a number of membrane proteins.
  • Formerly EC 2.1.1.24.
 1 U2FL04
Adenylate cyclase. [EC: 4.6.1.1]
ATP = 3',5'-cyclic AMP + diphosphate.
  • Also acts on dATP to form 3',5'-cyclic dAMP.
  • Requires pyruvate.
  • Activated by NAD(+) in presence of EC 2.4.2.31.
 1 A0A0B8QFF1