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CATH Superfamily 3.40.50.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4654: Vancomycin resistance protein B

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-alanine--D-alanine ligase. [EC: 6.3.2.4]
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
  • Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.
 52 A0A0E2HK38 A0A132PA69 A0A1A7S9Y0 A0A1A7SD67 B6ZHJ4 C0X1V2 C4NZP6 C7WYV3 J5B1L3 J5DPU9
(42 more...)
D-alanine--(R)-lactate ligase. [EC: 6.1.2.1]
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate.
  • The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
 2 C7WYV3 Q06893