View in Gene3D

CATH Superfamily 3.40.50.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12632: Phosphoribosylaminoimidazole carboxylase ATPase su...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5-(carboxyamino)imidazole ribonucleotide synthase. [EC: 6.3.4.18]
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
  • In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates.
  • Carboxyphosphate is the putative acyl phosphate intermediate.
  • Involved in the late stages of purine biosynthesis.
 68 A0A021X2P5 A0A068DB51 A0A090ESI5 A0A090FZP4 A0A0B4X3N8 A0A0E1WYB1 A0A0F6ASB0 A0A0H3AQ61 A0A0H3G8G9 A0A0M1W9Z5
(58 more...)
Phosphoribosylaminoimidazole carboxylase. [EC: 4.1.1.21]
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
 1 A0A1M4LCW2