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CATH Superfamily 3.40.50.1970

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7298: 2-deoxy-scyllo-inosose synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-deoxy-scyllo-inosose synthase. [EC: 4.2.3.124]
D-glucose-6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate.
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • Requires an NAD(+) cofactor, which is transiently reduced during the reaction.
  • The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex.
 8 A0A1D8GA04 Q2MF16 Q2MF70 Q2MFP1 Q4R0W3 Q53U19 Q6L738 Q9S5E2
2-epi-5-epi-valiolone synthase. [EC: 4.2.3.152]
D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate.
  • The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate.
  • It requires a divalent metal ion (Zn(2+) or Co(2+)) and an NAD(+) cofactor, which is transiently reduced during the reaction.
  • The enzyme is involved in the biosynthesis of C(7)N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A.
  • Cf. EC 4.2.3.154 and EC 4.2.3.155.
 1 Q9ZAE9
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