The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25374: Epoxide hydrolase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Soluble epoxide hydrolase. [EC: 3.3.2.10]
An epoxide + H(2)O = a glycol.
  • Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.
  • It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
  • The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76.
  • Like EC 3.3.2.9, it is probable that the reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • The enzyme can also use leukotriene A(4), the substrate of EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than leukotriene B(4) as the product.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
9 A0A0E8V1N1 A0A0H3LBG2 A0A0T9MJX3 A0A109ST58 A0A197IY14 A5TYK9 F8M027 L7N5E1 P96811
Microsomal epoxide hydrolase. [EC: 3.3.2.9]
Cis-stilbene oxide + H(2)O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
  • Involved in the metabolism of numerous xenobiotics, such as 1,3- butadiene oxide, styrene oxide and the polycyclic aromatic hydrocarbon benzo[a]pyrene 4,5-oxide.
  • In a series of oxiranes with a lipophilic substituent of sufficient size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2- disubstituted oxiranes serve as substrates or inhibitors of the enzyme, while trans-1,2-disubstituted, tri- and tetra-substituted oxiranes are not substrates.
  • The reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
9 A0A0E8V1N1 A0A0H3LBG2 A0A0T9MJX3 A0A109ST58 A0A197IY14 A5TYK9 F8M027 L7N5E1 P96811