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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115488: Triacylglycerol lipase, pancreatic, putative

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Triacylglycerol lipase. [EC: 3.1.1.3]
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
  • The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
 484 A0A023I9E2 A0A023I9E2 A0A024R2B5 A0A024R2B5 A0A059TA26 A0A059TA26 A0A061I1V4 A0A061I1V4 A0A075B781 A0A075B781
(474 more...)
Lipoprotein lipase. [EC: 3.1.1.34]
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
  • Hydrolyzes triacylglycerols in chylomicrons and very low-density lipoproteins (VLDL).
  • Also hydrolyzes diacylglycerol.
 398 A0A060VY20 A0A060VY20 A0A060Y643 A0A060Y643 A0A061IKA1 A0A061IKA1 A0A067XH99 A0A067XH99 A0A075EIH3 A0A075EIH3
(388 more...)
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4, and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 338 A0A0J9QUG2 A0A0J9QUG2 A0A0J9QW48 A0A0J9QW48 A0A0J9QYW6 A0A0J9QYW6 A0A0J9R5Q1 A0A0J9R5Q1 A0A0J9REI3 A0A0J9REI3
(328 more...)
Phospholipase A(1). [EC: 3.1.1.32]
Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate.
  • Has a much broader specificity than EC 3.1.1.4.
 116 A0A0Q9X1M9 A0A0Q9X1M9 A0A0R3NFV4 A0A0R3NFV4 A2VBC4 A2VBC4 B3MT04 B3MT04 B3MT05 B3MT05
(106 more...)
Galactolipase. [EC: 3.1.1.26]
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D- galactosyl-sn-glycerol + 2 carboxylates.
  • Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D- galactosyl)-D-glycerol, and phosphatidylcholine and other phospholipids.
 12 A5PK46 A5PK46 P17892 P17892 P54317 P54317 P54318 P54318 P81139 P81139
(2 more...)
Phospholipase A(2). [EC: 3.1.1.4]
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
  • Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
 10 P49369 P49369 P51528 P51528 P53357 P53357 Q06478 Q06478 Q3ZU95 Q3ZU95
Peptidylprolyl isomerase. [EC: 5.2.1.8]
Peptidylproline (omega=180) = peptidylproline (omega=0).
  • The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A.
  • Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli.
  • The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
 2 A0A0J7L1A3 A0A0J7L1A3
Signal peptidase I. [EC: 3.4.21.89]
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
  • Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity.
  • Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein.
  • Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane.
  • Belongs to peptidase family S26.
  • Formerly EC 3.4.99.36.
 2 A0A0J7KJC0 A0A0J7KJC0