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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115324: Lipase 4, isoform A

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Triacylglycerol lipase. [EC: 3.1.1.3]
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
  • The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
 46 A0A0P4U7J0 A0A0P4U7J0 A2QN29 A2QN29 B7PJN0 B7PJN0 B7PX98 B7PX98 B7QDU6 B7QDU6
(36 more...)
Sterol esterase. [EC: 3.1.1.13]
A steryl ester + H(2)O = a sterol + a fatty acid.
  • A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols.
  • Activated by bile salts.
 36 A0A0F7Z6I0 A0A0F7Z6I0 A6ZZI1 A6ZZI1 F7EC56 F7EC56 G2WHP8 G2WHP8 G2WIL4 G2WIL4
(26 more...)
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4, and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 2 A0A0P4U7J0 A0A0P4U7J0