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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 62961: Cytotoxin/hemolysin TlyA

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (cytidine(1920)-2'-O)-methyltransferase. [EC: 2.1.1.226]
S-adenosyl-L-methionine + cytidine(1920) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(1920) in 23S rRNA.
  • The bifunctional enzyme from Mycobacterium tuberculosis 2'-O- methylates cytidine(1920) in helix 69 of 23S rRNA and cytidine(1409) in helix 44 of 16S rRNA (cf. EC 2.1.1.227).
  • These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
 54 A0A045KH60 A0A045KH60 A0A0H3L9R5 A0A0H3L9R5 A0A0H3M4J2 A0A0H3M4J2 A0A0H3P312 A0A0H3P312 A0A0K2HVV4 A0A0K2HVV4
(44 more...)
16S rRNA (cytidine(1409)-2'-O)-methyltransferase. [EC: 2.1.1.227]
S-adenosyl-L-methionine + cytidine(1409) in 16S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(1409) in 16S rRNA.
  • The bifunctional enzyme from Mycobacterium tuberculosis 2'-O- methylates cytidine(1409) in helix 44 of 16S rRNA and cytidine(1920) in helix 69 of 23S rRNA (cf. EC 2.1.1.226).
 36 A0A045KH60 A0A045KH60 A0A0H3L9R5 A0A0H3L9R5 A0A0H3M4J2 A0A0H3M4J2 A0A0H3P312 A0A0H3P312 A0A0K2HVV4 A0A0K2HVV4
(26 more...)