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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 136212: Glycine N-methyltransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glycine N-methyltransferase. [EC: 2.1.1.20]
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
  • Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
  • Inhibited by 5-methyltetrahydrofolate pentaglutamate.
  • Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
 150 A0A060XET2 A0A060XET2 A0A061IQF6 A0A061IQF6 A0A087XXH5 A0A087XXH5 A0A091E0V6 A0A091E0V6 A0A096NI74 A0A096NI74
(140 more...)
Glycine/sarcosine N-methyltransferase. [EC: 2.1.1.156]
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
 16 B4GZC0 B4GZC0 B4K763 B4K763 B4M099 B4M099 B4NI05 B4NI05 B4PPD2 B4PPD2
(6 more...)
Glycine/sarcosine/dimethylglycine N-methyltransferase. [EC: 2.1.1.162]
3 S-adenosyl-L-methionine + glycine = 3 S-adenosyl-L-homocysteine + betaine.
  • Unlike EC 2.1.1.156, EC 2.1.1.157 and EC 2.1.1.161, this enzyme, from the halophilic methanoarchaeon Methanohalophilus portucalensis, can methylate glycine and all of its intermediates to form the compatible solute betaine.
 14 B4GZC0 B4GZC0 B4K763 B4K763 B4M099 B4M099 B4NI05 B4NI05 B4PPD2 B4PPD2
(4 more...)
Histamine N-methyltransferase. [EC: 2.1.1.8]
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)- methylhistamine.
    		 2 M5RLB6 M5RLB6
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