The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 136200: 2-methyl-6-phytyl-1,4-hydroquinone methyltransfera...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-methyl-6-phytyl-1,4-hydroquinone methyltransferase. [EC: 2.1.1.295]
(1) S-adenosyl-L-methionine + 2-methyl-6-phytylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytylbenzene-1,4-diol. (2) S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4- diol = S-adenosyl-L-homocysteine + plastoquinol. (3) S-adenosyl-L-methionine + 6-geranylgeranyl-2-methylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 6-geranylgeranyl-2,3-dimethylbenzene-1,4- diol.
  • Involved in the biosynthesis of plastoquinol, as well as vitamin E (tocopherols and tocotrienols).
9 A0A0E0Q4S8 A0A0E0RK08 A0A161VDL9 A0A178VHS6 A2ZMQ9 P23525 Q2QM69 Q6ZLD3 Q9LY74
Erythromycin 3''-O-methyltransferase. [EC: 2.1.1.254]
(1) S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A. (2) S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B.
  • The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A.
  • It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154.
5 A0A0K6JKB9 A0A0K6K5J1 A0A0K6L230 A4F7P5 T2S321
CATH-Gene3D is a Global Biodata Core Resource Learn more...