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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 136027: N2,N2-dimethylguanosine tRNA methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(26)-N(2))-dimethyltransferase. [EC: 2.1.1.216]
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L- homocysteine + N(2)-dimethylguanine(26) in tRNA.
  • The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
  • In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA.
  • Formerly EC 2.1.1.32.
 16 A0A063ZE60 A0A0H1R5R5 A0A101GPQ6 A0A101H2G5 A0A117MI21 A0A162QC43 A0A1D2RFG8 A0A1G9ALW9 A2SRK9 A3CW75
(6 more...)
TRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase. [EC: 2.1.1.215]
4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA = 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)- dimethylguanine(27) in tRNA.
  • The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216).
  • However, it catalyzes the double methylation of guanines at both positions 26 and 27 of tRNA.
  • Formerly EC 2.1.1.32.
 1 A0A1M4MNG3