The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 135978: Malonyl-[acyl-carrier protein] O-methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malonyl-[acyl-carrier protein] O-methyltransferase. [EC: 2.1.1.197]
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L- homocysteine + malonyl-[acyl-carrier protein] methyl ester.
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
8 A0A095SIA1 A0A1L8YNY9 A9KG74 B4WYA2 L0WH91 Q0VMD3 Q2KXN6 Q83CU8
Dethiobiotin synthase. [EC: 6.3.3.3]
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
  • CTP has half the activity of ATP.
1 Q2KXN6
CATH-Gene3D is a Global Biodata Core Resource Learn more...