The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135943: Probable tRNA (guanine(26)-N(2))-dimethyltransfera...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(26)-N(2))-dimethyltransferase. [EC: 2.1.1.216]
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L- homocysteine + N(2)-dimethylguanine(26) in tRNA.
  • The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
  • In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA.
  • Formerly EC 2.1.1.32.
168 A0A076LKJ4 A0A076LKJ4 A0A089ZHE2 A0A089ZHE2 A0A090I2V5 A0A090I2V5 A0A0K1E0I5 A0A0K1E0I5 A0A0M0BP70 A0A0M0BP70
(158 more...)
TRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase. [EC: 2.1.1.215]
4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA = 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)- dimethylguanine(27) in tRNA.
  • The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216).
  • However, it catalyzes the double methylation of guanines at both positions 26 and 27 of tRNA.
  • Formerly EC 2.1.1.32.
6 A8UVZ8 A8UVZ8 O67010 O67010 W0DHD4 W0DHD4
Transferred entry: 2.1.1.213, 2.1.1.214, 2.1.1.215 and 2.1.1.216. [EC: 2.1.1.32]
    4 B9SIU2 B9SIU2 G4RKK8 G4RKK8
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