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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135832: Malonyl-[acyl-carrier protein] O-methyltransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malonyl-[acyl-carrier protein] O-methyltransferase. [EC: 2.1.1.197]
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L- homocysteine + malonyl-[acyl-carrier protein] methyl ester.
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
 3092 A0A009FKJ8 A0A009GLV7 A0A009H8Y3 A0A009HI94 A0A009HQG8 A0A009KU83 A0A009N3Y9 A0A009QLY0 A0A009QN94 A0A009SE92
(3082 more...)
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4, and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 2 B3PI89 C5BMZ8
8-amino-7-oxononanoate synthase. [EC: 2.3.1.47]
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
  • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
  • Pimeloyl-CoA can be used with lower efficiency.
 1 A0A0H6KE02
Dethiobiotin synthase. [EC: 6.3.3.3]
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
  • CTP has half the activity of ATP.
 1 A5ZHP9