The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135593: Salicylic acid carboxyl methyltransferase

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Jasmonate O-methyltransferase. [EC: 2.1.1.141]
S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyl jasmonate.
  • 9,10-dihydrojasmonic acid is a poor substrate for the enzyme.
  • The enzyme does not convert 12-oxo-phytodienoic acid (a precursor of jasmonic acid), salicylic acid, benzoic acid, linolenic acid or cinnamic acid into their corresponding methyl esters.
  • Enzyme activity is inhibited by the presence of divalent cations, e.g., Ca(2+), Cu(2+), Mg(2+) and Zn(2+).
50 A0A088Q2I5 A0A0B2NW97 A0A0B2NYF4 A0A0B2NZ12 A0A0B2PDN6 A0A0B2PU51 A0A0B2Q6J3 A0A0B2QI31 A0A0B2QMV6 A0A0B2QN03
(40 more...)
Caffeine synthase. [EC: 2.1.1.160]
(1) S-adenosyl-L-methionine + 3,7-dimethylxanthine = S-adenosyl-L- homocysteine + 1,3,7-trimethylxanthine. (2) S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L- homocysteine + 1,3,7-trimethylxanthine. (3) S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L- homocysteine + 3,7-dimethylxanthine.
  • Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
15 A0A061DEC0 A0A068VAE8 A4GE70 G9BZJ5 G9BZJ7 G9BZJ8 K9MNV5 K9MPP6 L0BUM3 L0BWK3
(5 more...)
Salicylate carboxymethyltransferase. [EC: 2.1.1.274]
S-adenosyl-L-methionine + salicylate = S-adenosyl-L-homocysteine + methyl salicylate.
  • The enzyme, which is found in flowering plants, also has the activity of EC 2.1.1.273.
  • Formerly EC 2.1.1.n9.
5 A0A088Q097 A0A088QFL1 D9J100 Q6XMI3 Q9SPV4
Theobromine synthase. [EC: 2.1.1.159]
S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine.
  • Can also catalyze the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
  • This is the third enzyme in the caffeine biosynthesis pathway.
5 A0A096VHZ7 Q7FRH9 Q84PP7 Q8H0G0 Q9AVJ9
Benzoate O-methyltransferase. [EC: 2.1.1.273]
S-adenosyl-L-methionine + benzoate = S-adenosyl-L-homocysteine + methyl benzoate.
  • While the enzyme from the plant Zea mays is specific for benzoate, the enzymes from Arabidopsis species and Clarkia breweri also catalyze the reaction of EC 2.1.1.274.
  • In snapdragon (Antirrhinum majus) two isoforms are found, one specific for benzoate and one that is also active toward salicylate.
  • The volatile product is an important scent compound in some flowering species.
4 A0A088Q0D9 D9J100 D9J101 Q6XMI3
Anthranilate O-methyltransferase. [EC: 2.1.1.277]
S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + O-methyl anthranilate.
  • In the plant maize (Zea mays), the isoforms AAMT1 and AAMT2 are specific for anthranilate while AAMT3 also has the activity of EC 2.1.1.273.
3 B6SU46 D9J0Z7 D9J100
7-methylxanthosine synthase. [EC: 2.1.1.158]
S-adenosyl-L-methionine + xanthosine = S-adenosyl-L-homocysteine + 7-methylxanthosine.
  • The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates.
  • The enzyme does not have N(1)- or N(3)- methylation activity.
  • This is the first methylation step in the production of caffeine.
3 A4GE69 E5Q8J7 Q9AVK0
Nicotinate N-methyltransferase. [EC: 2.1.1.7]
S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate.
    2 C3VIX6 L7RZC0
    Indole-3-acetate O-methyltransferase. [EC: 2.1.1.278]
    S-adenosyl-L-methionine + (indol-3-yl)acetate = S-adenosyl-L-homocysteine + methyl (indol-3-yl)acetate.
    • The enzyme is found in plants and is important for regulation of the plant hormone (indol-3-yl)acetate.
    • The product, methyl (indol-3-yl)acetate is inactive as hormone.
    • Formerly EC 2.1.1.n10.
    2 Q0J998 Q9FLN8