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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135188: 23S rRNA m1G745 methyltransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
23S rRNA (guanine(745)-N(1))-methyltransferase. [EC: 2.1.1.187]
S-adenosyl-L-methionine + guanine(745) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(745) in 23S rRNA.
  • The enzyme specifically methylates guanine(745) at N(1) in 23S rRNA.
  • Formerly EC 2.1.1.51.
 106 A0A024HDB6 A0A069Q4U6 A0A085PCF2 A0A085TCW6 A0A085TPL3 A0A0B7D4A7 A0A0C1VX18 A0A0D0TCH9 A0A0F6LVA0 A0A0F7A574
(96 more...)
Transferred entry: 2.1.1.187 and 2.1.1.188. [EC: 2.1.1.51]
    		5 A0A0E4G5N4 A7K0R3 B6EIJ6 C3K5D4 Q1I613
    16S rRNA (guanine(966)-N(2))-methyltransferase. [EC: 2.1.1.171]
    S-adenosyl-L-methionine + guanine(966) in 16S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(966) in 16S rRNA.
    • The enzyme efficiently methylates guanine(966) of the assembled 30S subunits in vitro.
    • Protein-free 16S rRNA is not a substrate for RsmD.
    • The enzyme specifically methylates guanine(966) at N(2) in 16S rRNA.
    • Formerly EC 2.1.1.52.
    		 3 V7E766 W6VGH8 W6VUH0
    23S rRNA (guanine(748)-N(1))-methyltransferase. [EC: 2.1.1.188]
    S-adenosyl-L-methionine + guanine(748) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(748) in 23S rRNA.
    • The enzyme specifically methylates guanine(748) at N(1) in 23S rRNA.
    • The methyltransferase RlmA(II) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae.
    • Formerly EC 2.1.1.51.
    		 3 A0A081ECD6 L8MGH2 Q9S1M6
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