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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135174: Glycine N-methyltransferase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sarcosine/dimethylglycine N-methyltransferase. [EC: 2.1.1.157]
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
 13 A0A0D6JI85 A0A0F7KNX7 A0A0G3EG49 A0A0X8XB40 A1WXM9 D5EA51 F4Y2P8 H2CAA9 I3BQZ9 K9YGK5
(3 more...)
Dimethylglycine N-methyltransferase. [EC: 2.1.1.161]
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine.
  • This enzyme, from the marine cyanobacterium Synechococcus sp. strain WH8102, differs from EC 2.1.1.157 in that it cannot use sarcosine as an alternative substrate.
  • Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.
 8 A0A162DZC5 A0A163CWI6 A0A163EYJ7 A0A163LXL1 A0A163PWD2 A0A163T2R1 A0A163UJG3 U5DKV9
Glycine/sarcosine N-methyltransferase. [EC: 2.1.1.156]
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
 5 A0A0M6Y3Y8 A0A0P7X7I3 A0A1L8QHE1 Q9KJ20 U7GP48
Glycine N-methyltransferase. [EC: 2.1.1.20]
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
  • Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
  • Inhibited by 5-methyltetrahydrofolate pentaglutamate.
  • Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
 2 A0A0B3RPI1 S9Q394
Trans-aconitate 2-methyltransferase. [EC: 2.1.1.144]
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.
  • Also catalyzes the formation of the methyl monoester of cis- aconitate, isocitrate and citrate, but more slowly.
  • While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)- pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145).
 1 U2FYD2
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