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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135011: Leucine carboxyl methyltransferase 1

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Phosphatase 2A protein]-leucine-carboxy methyltransferase. [EC: 2.1.1.233]
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
  • Methylates the C-terminal leucine of phosphatase 2A.
  • A key regulator of protein phosphatase 2A.
  • The methyl ester is hydrolyzed by EC 3.1.1.89.
  • Occurs mainly in the cytoplasm, Golgi region and late endosomes.
 46 A0A0B0DWD7 A0A0B0DWD7 A0A0J5Q0P7 A0A0J5Q0P7 A0A1H6PY21 A0A1H6PY21 A0A1I9FSD9 A0A1I9FSD9 B0XRP6 B0XRP6
(36 more...)
TRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)- methoxycarbonyltransferase. [EC: 2.3.1.231]
S-adenosyl-L-methionine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) = S-adenosyl-L- homocysteine + wybutosine(37) in tRNA(Phe).
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.1.1.290.
 30 A0A1H6PZI0 A0A1H6PZI0 N1NWW8 N1NWW8 O60157 O60157 O60294 O60294 Q08282 Q08282
(20 more...)
TRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase. [EC: 2.1.1.290]
S-adenosyl-L-methionine + 7-((3S)-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-3-amino-3- (methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe).
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.3.1.231.
 30 A0A1H6PZI0 A0A1H6PZI0 N1NWW8 N1NWW8 O60157 O60157 O60294 O60294 Q08282 Q08282
(20 more...)
Creatine kinase. [EC: 2.7.3.2]
ATP + creatine = ADP + phosphocreatine.
  • N-ethylglycocyamine can also act as acceptor.
 6 A0A0B2PMK1 A0A0B2PMK1 A0A0B2S8E0 A0A0B2S8E0 A0A0R4J4T5 A0A0R4J4T5
Glycerol-3-phosphate dehydrogenase. [EC: 1.1.5.3]
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
  • An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.
  • In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.
  • In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.
  • This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.
  • Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9).
  • The enzyme is activated by calcium.
  • Formerly EC 1.1.2.1 and EC 1.1.99.5.
 4 A0A0A2VPS7 A0A0A2VPS7 J4KKP8 J4KKP8
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