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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 133018: Putative coclaurine N-methyltransferase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(S)-tetrahydroprotoberberine N-methyltransferase. [EC: 2.1.1.122]
S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14- tetrahydroprotoberberine.
  • Involved in the biosynthesis of isoquinoline alkaloids in plants.
 4 C3SBS8 C3SBU4 C3SBU5 Q108P1
Cyclopropane-fatty-acyl-phospholipid synthase. [EC: 2.1.1.79]
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid.
  • Adds a methylene group across the 9,10 position of a Delta(9)- olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol forming a cyclopropane derivative (cf. EC 2.1.1.16).
 4 A0A0B2R811 A0A0B2RIP8 I1JTZ7 I1K8E7
(S)-coclaurine-N-methyltransferase. [EC: 2.1.1.140]
S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine.
  • The enzyme is specific for the (S)-isomer of coclaurine.
  • Norcoclaurine can also act as an acceptor.
 2 A0A0B4VG18 Q5C9L6
Pavine N-methyltransferase. [EC: 2.1.1.300]
S-adenosyl-L-methionine + (+-)-pavine = S-adenosyl-L-homocysteine + N-methylpavine.
  • The enzyme, isolated from the plant Thalictrum flavum, also methylates (R,S)-stylopine and (S)-scoulerine (11%) with lower activity (14% and 11%, respectively).
  • Formerly EC 2.1.1.n14.
 1 C3SBW0
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. [EC: 2.1.1.115]
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4- tetrahydroisoquinoline.
  • Broad substrate specificity for (RS)-1-benzyl-1,2,3,4- tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine.
  • Both R- and S-enantiomers are methylated.
  • Participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants.
  • The physiological substrate is likely to be coclaurine.
  • Was earlier termed norreticuline N-methyltransferase.
  • However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1- benzyl-1,2,3,4-tetrahydroisoquinolines.
 1 Q948P7