The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 131649: Histamine N-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histamine N-methyltransferase activity GO:0046539
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).
9 Q0V9P1 (/ISS) Q4SBY6 (/ISS) Q58DV7 (/ISS) Q5R7C3 (/ISS) Q5U4V2 (/ISS) Q6DC37 (/ISS) Q7SYS9 (/ISS) Q91VF2 (/ISS) Q9EST2 (/ISS)
Histamine N-methyltransferase activity GO:0046539
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).
3 E1C378 (/IDA) P50135 (/IDA) Q01984 (/IDA)
N-methyltransferase activity GO:0008170
Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
1 Q91VF2 (/IDA)
Histamine N-methyltransferase activity GO:0046539
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).
1 Q91VF2 (/ISO)
Histamine N-methyltransferase activity GO:0046539
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).
1 P50135 (/TAS)
Selenol Se-methyltransferase activity GO:0098603
Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine.
1 Q01984 (/TAS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histamine catabolic process GO:0001695
The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
10 Q01984 (/ISS) Q0V9P1 (/ISS) Q4SBY6 (/ISS) Q58DV7 (/ISS) Q5R7C3 (/ISS) Q5U4V2 (/ISS) Q6DC37 (/ISS) Q7SYS9 (/ISS) Q91VF2 (/ISS) Q9EST2 (/ISS)
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
8 Q0V9P1 (/ISS) Q4SBY6 (/ISS) Q58DV7 (/ISS) Q5R7C3 (/ISS) Q5U4V2 (/ISS) Q6DC37 (/ISS) Q7SYS9 (/ISS) Q9EST2 (/ISS)
Regulation of neurotransmitter levels GO:0001505
Any process that modulates levels of neurotransmitter.
1 Q91VF2 (/TAS)
Histamine catabolic process GO:0001695
The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
1 P50135 (/IDA)
Histamine catabolic process GO:0001695
The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
1 Q91VF2 (/ISO)
Selenium compound metabolic process GO:0001887
The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
1 Q01984 (/TAS)
Response to tumor cell GO:0002347
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.
1 Q01984 (/IEP)
Histidine catabolic process GO:0006548
The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
1 P50135 (/TAS)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 Q01984 (/IEP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q01984 (/IEP)
Respiratory gaseous exchange GO:0007585
The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
1 P50135 (/TAS)
Response to amine GO:0014075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 Q01984 (/IEP)
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
1 P50135 (/IDA)
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
1 Q91VF2 (/ISO)
Response to immobilization stress GO:0035902
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
1 Q01984 (/IEP)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 Q01984 (/IEP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q01984 (/IEP)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q01984 (/IEP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 P50135 (/IMP)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q91VF2 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q01984 (/ISS) Q0V9P1 (/ISS) Q4SBY6 (/ISS) Q58DV7 (/ISS) Q5R7C3 (/ISS) Q5U4V2 (/ISS) Q6DC37 (/ISS) Q7SYS9 (/ISS) Q91VF2 (/ISS) Q9EST2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P50135 (/TAS) Q01984 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P50135 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q91VF2 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q01984 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P50135 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q91VF2 (/ISO)