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CATH Superfamily 3.40.50.1440

Tubulin/FtsZ, GTPase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Tubulin/FtsZ, GTPase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 269: Tubulin beta chain, putative

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 3 A0A161MN97 A0A161MNA3 A0A170Y0D9
TRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase. [EC: 2.1.1.205]
S-adenosyl-L-methionine + cytidine(32)/guanosine(34) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(32)/2'-O- methylguanosine(34) in tRNA.
  • The enzyme from Saccharomyces cerevisiae catalyzes the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNA(Phe), tRNA(Trp) and, possibly, tRNA(Leu).
 1 W6UTI4
Tubulin GTPase. [EC: 3.6.5.6]
GTP + H(2)O = GDP + phosphate.
  • An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.
  • Formerly EC 3.6.1.51.
 1 J9Z1N5