The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
TPP-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12951: Pyruvate dehydrogenase [cytochrome]

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate dehydrogenase (quinone). [EC: 1.2.5.1]
Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol.
  • This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone.
  • Does not accept menaquinone.
  • Activity is greatly enhanced by lipids.
  • Requires thiamine diphosphate.
  • The enzyme can also form acetoin.
325 A0A017IL41 A0A024L4U9 A0A026UKJ3 A0A028AKB7 A0A029I727 A0A029IZS9 A0A029KYY3 A0A029LU19 A0A029PQT2 A0A062Y2H0
(315 more...)
Deleted entry. [EC: 1.2.2.2]
    108 A0A026UKJ3 A0A028AKB7 A0A029I727 A0A029IZS9 A0A066SYL5 A0A070D562 A0A070DEA7 A0A070FB20 A0A093D8T3 A0A0A1A666
    (98 more...)
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