The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Glucose-6-phosphate isomerase like protein; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20654: Glucose-6-phosphate isomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucose-6-phosphate isomerase activity GO:0004347
Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
2 P06745 (/IDA) Q6P6V0 (/IDA)
Glucose-6-phosphate isomerase activity GO:0004347
Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
1 P06745 (/IMP)
Glucose-6-phosphate isomerase activity GO:0004347
Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.
1 P06744 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P06745 (/IPI)
Intramolecular transferase activity GO:0016866
Catalysis of the transfer of a functional group from one position to another within a single molecule.
1 Q6P6V0 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P06744 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P06745 (/ISO)
Monosaccharide binding GO:0048029
Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H
1 Q6P6V0 (/IPI)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P06745 (/IMP)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
1 P06745 (/IMP)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 Q6P6V0 (/IDA)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 P06744 (/NAS)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 P06744 (/TAS)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 P06745 (/IDA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 P06745 (/IMP)
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
1 P06744 (/TAS)
Hemostasis GO:0007599
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
1 P06744 (/TAS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 Q6P6V0 (/IEP)
Methylglyoxal biosynthetic process GO:0019242
The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
1 Q6P6V0 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q6P6V0 (/IEP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 Q6P6V0 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 Q6P6V0 (/IEP)
Erythrocyte homeostasis GO:0034101
Any process of regulating the production and elimination of erythrocytes within an organism.
1 P06745 (/IMP)
Response to immobilization stress GO:0035902
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
1 Q6P6V0 (/IEP)
Response to muscle stretch GO:0035994
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
1 Q6P6V0 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P06745 (/IMP)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 Q6P6V0 (/IMP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 Q6P6V0 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P06744 (/TAS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q6P6V0 (/IMP)
Aldehyde catabolic process GO:0046185
The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.
1 Q6P6V0 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q6P6V0 (/IEP)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
1 P06744 (/IDA)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
1 P06745 (/ISO)
Glucose 6-phosphate metabolic process GO:0051156
The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
1 Q6P6V0 (/IDA)
Glycolytic process through glucose-6-phosphate GO:0061620
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.
1 P06745 (/IC)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
1 P06744 (/TAS)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A0A0MTS2 (/IDA) K7EQ48 (/IDA) P06744 (/IDA) Q6P6V0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A0A0MTS2 (/IDA) K7EQ48 (/IDA) P06744 (/IDA) P06745 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A0A0MTS2 (/IDA) K7EQ48 (/IDA) P06744 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P06744 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P06745 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P06745 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6P6V0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P06745 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P06744 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P06745 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P06744 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P06745 (/ISO)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 P06744 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6P6V0 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P06745 (/IDA)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
1 P06745 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P06744 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P06745 (/ISO)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
1 P06744 (/TAS)