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CATH Superfamily 3.40.50.10330

Probable inorganic polyphosphate/atp-NAD kinase; domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Probable inorganic polyphosphate/atp-NAD kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6271: Sphingosine kinase 2, isoform CRA_c

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diacylglycerol kinase (ATP). [EC: 2.7.1.107]
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
  • Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol.
  • Activity is stimulated by certain phospholipids.
  • In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger.
  • cf. EC 2.7.1.174.
 38 A4D1U5 A4D1U5 B3LZJ5 B3LZJ5 B3M7F2 B3M7F2 B3MVR5 B3MVR5 B3NF21 B3NF21
(28 more...)
Sphingosine kinase. [EC: 2.7.1.91]
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
  • The enzyme is involved in the production of sphingolipid metabolites.
  • It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine.
  • The exact substrate range depends on the species.
 30 A0A024QZH5 A0A024QZH5 A0A0B2NX89 A0A0B2NX89 A0A178V174 A0A178V174 F2Y4A3 F2Y4A3 O14159 O14159
(20 more...)
NAD(+) kinase. [EC: 2.7.1.23]
ATP + NAD(+) = ADP + NADP(+).
    		 22 B3LZJ5 B3LZJ5 B3M7F2 B3M7F2 B3MVR5 B3MVR5 B3NF21 B3NF21 B3NUD3 B3NUD3
    (12 more...)
    Ceramide kinase. [EC: 2.7.1.138]
    ATP + ceramide = ADP + ceramide 1-phosphate.
      		 22 A0A0B2QDR3 A0A0B2QDR3 A0A0B2R0K3 A0A0B2R0K3 A0A151QX93 A0A151QX93 B7PYF2 B7PYF2 B7QAB7 B7QAB7
      (12 more...)
      Acylglycerol kinase. [EC: 2.7.1.94]
      ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
      • Acts on both 1- and 2-acylglycerols.
      		 12 A4D1U5 A4D1U5 Q53H12 Q53H12 Q5RED7 Q5RED7 Q7ZW00 Q7ZW00 Q7ZYJ3 Q7ZYJ3
      (2 more...)
      Type 1 galactoside alpha-(1,2)-fucosyltransferase. [EC: 2.4.1.69]
      GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-R.
      • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
      • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
      • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
      • Formerly EC 2.4.1.89.
      		 2 G3HZW5 G3HZW5
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