View in Gene3D

CATH Superfamily 3.40.470.10

Uracil-DNA glycosylase-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Uracil-DNA glycosylase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4997: Uracil-DNA glycosylase, family 4

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-directed DNA polymerase. [EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a primer which may be DNA or RNA.
  • See also EC 2.7.7.49.
 68 A0A075WHL4 A0A075WHL4 A0A0A0HF76 A0A0A0HF76 A0A0B3BAS4 A0A0B3BAS4 A0A0B6WXB8 A0A0B6WXB8 A0A0D0Q8Z8 A0A0D0Q8Z8
(58 more...)
Uracil-DNA glycosylase. [EC: 3.2.2.27]
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
  • Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
  • Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
 8 A0A101E0V1 A0A101E0V1 O28007 O28007 Q5SKC5 Q5SKC5 Q96YD0 Q96YD0
Hydroxyacylglutathione hydrolase. [EC: 3.1.2.6]
S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.
  • Also hydrolyzes S-acetoacetylglutathione, more slowly.
  • Formerly EC 3.1.2.8.
 2 U2WRX9 U2WRX9
Cytosine deaminase. [EC: 3.5.4.1]
Cytosine + H(2)O = uracil + NH(3).
  • Also acts on 5-methylcytosine.
 2 A6FMM6 A6FMM6