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CATH Superfamily 3.40.470.10

Uracil-DNA glycosylase-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Uracil-DNA glycosylase-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4994: G/U mismatch-specific DNA glycosylase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Double-stranded uracil-DNA glycosylase. [EC: 3.2.2.28]
Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.
  • No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N(4)-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing Escherichia coli.
  • Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
  • Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
 1224 A0A017I8W5 A0A017I8W5 A0A023V4V9 A0A023V4V9 A0A023Z2M9 A0A023Z2M9 A0A024KPE6 A0A024KPE6 A0A025CYX6 A0A025CYX6
(1214 more...)
Thymine-DNA glycosylase. [EC: 3.2.2.29]
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.
  • Thymine-DNA glycosylase is part of the DNA-repair machinery.
  • Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair.
  • The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
 4 P56581 P56581 Q13569 Q13569
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