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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52545: Chalcone synthase family protein

There are 17 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Naringenin-chalcone synthase. [EC: 2.3.1.74]
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).
  • In the presence of NADH and a reductase, 6'-deoxychalcone is produced.
 652 A0A023W453 A0A023W453 A0A060D9S4 A0A060D9S4 A0A097EYS7 A0A097EYS7 A0A097EYT1 A0A097EYT1 A0A097EYT2 A0A097EYT2
(642 more...)
Trihydroxystilbene synthase. [EC: 2.3.1.95]
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO(2).
  • Not identical with EC 2.3.1.74 or EC 2.3.1.146.
 64 A2ICC6 A2ICC6 A5AEM3 A5AEM3 A5C9M2 A5C9M2 B2MXD0 B2MXD0 B2MXD1 B2MXD1
(54 more...)
3,5-dihydroxybiphenyl synthase. [EC: 2.3.1.177]
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO(2).
  • A polyketide synthase that is involved in the production of the phytoalexin aucuparin.
  • 2-hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208).
  • This enzyme uses the same starter substrate as EC 2.3.1.151.
 16 A0A1B1PJB0 A0A1B1PJB0 A0A1B1PJB7 A0A1B1PJB7 H2FL89 H2FL89 H2FL90 H2FL90 H2FL91 H2FL91
(6 more...)
Pinosylvin synthase. [EC: 2.3.1.146]
3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO(2).
  • Not identical with EC 2.3.1.74 or EC 2.3.1.95.
 10 P48407 P48407 P48408 P48408 Q02323 Q02323 Q9MBA9 Q9MBA9 Q9MBB0 Q9MBB0
Acridone synthase. [EC: 2.3.1.159]
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N- methylacridone + 3 CO(2).
    		 8 Q9FSC0 Q9FSC0 Q9FSC1 Q9FSC1 Q9FSC2 Q9FSC2 U3KRF0 U3KRF0
    Curcumin synthase. [EC: 2.3.1.217]
    Feruloyl-CoA + feruloylacetyl-CoA + H(2)O = 2 CoA + curcumin + CO(2).
    • A polyketide synthase from the plant Curcuma longa (turmeric).
    • Three isoforms exist, CURS1, CURS2 and CURS3.
    • While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well (see EC 2.3.1.219).
    		 6 C0SVZ6 C0SVZ6 C6L7V8 C6L7V8 C6L7V9 C6L7V9
    4-hydroxycoumarin synthase. [EC: 2.3.1.208]
    Malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO(2).
    • The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177).
    		 4 D2DRC4 D2DRC4 D2DRC5 D2DRC5
    Benzalacetone synthase. [EC: 2.3.1.212]
    4-coumaroyl-CoA + malonyl-CoA + H(2)O = 2 CoA + 4-hydroxybenzalacetone + 2 CO(2).
    • A polyketide synthase that catalyzes the C(6)-C(4) skeleton of phenylbutanoids in higher plants.
    		 4 B0LDU5 B0LDU5 Q94FV7 Q94FV7
    2,4,6-trihydroxybenzophenone synthase. [EC: 2.3.1.220]
    3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO(2).
    • Involved in the biosynthesis of plant xanthones.
    • The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151).
    		 4 L7NCQ3 L7NCQ3 Q8SAS8 Q8SAS8
    Phloroisovalerophenone synthase. [EC: 2.3.1.156]
    Isovaleryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO(2) + 3-methyl-1-(2,4,6- trihydroxyphenyl)butan-1-one.
    • Closely related to EC 2.3.1.74.
    • The product, 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one, is phloroisovalerophenone.
    • Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone.
    • The products are intermediates in the biosynthesis of the bitter (alpha) acids in hops (Humulus lupulus).
    		 4 O80400 O80400 Q9SLX9 Q9SLX9
    2,3',4,6-tetrahydroxybenzophenone synthase. [EC: 2.3.1.151]
    3 malonyl-CoA + 3-hydroxybenzoyl-CoA = 4 CoA + 2,3',4,6- tetrahydroxybenzophenone + 3 CO(2).
    • Involved in the biosynthesis of plant xanthones.
    • Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA (cf. EC 2.3.1.220).
    		 4 K4HQC0 K4HQC0 Q8SAS8 Q8SAS8
    Demethoxycurcumin synthase. [EC: 2.3.1.219]
    (1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H(2)O = 2 CoA + demethoxycurcumin + CO(2). (2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H(2)O = 2 CoA + bisdemethoxycurcumin + CO(2).
    • A polyketide synthase from the plant Curcuma longa (turmeric).
    • Three isoforms exist, CURS1, CURS2 and CURS3.
    • While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217), CURS3 can accept 4-coumaroyl-CoA equally well.
    		 2 C6L7V9 C6L7V9
    Phenylpropanoylacetyl-CoA synthase. [EC: 2.3.1.218]
    (1) Feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO(2) + CoA. (2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO(2) + CoA.
    • The enzyme has been characterized from the plant Curcuma longa (turmeric).
    • It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.
    		 2 C0SVZ5 C0SVZ5
    8-amino-7-oxononanoate synthase. [EC: 2.3.1.47]
    Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
    • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
    • Pimeloyl-CoA can be used with lower efficiency.
    		 2 D0EVE3 D0EVE3
    3,5,7-trioxododecanoyl-CoA synthase. [EC: 2.3.1.206]
    3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO(2).
    • A polyketide synthase catalyzing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.
    • The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalyzed by EC 4.4.1.26.
    		 2 B1Q2B6 B1Q2B6
    5,7-dihydroxy-2-methylchromone synthase. [EC: 2.3.1.216]
    5 malonyl-CoA = 5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO(2) + H(2)O.
    • A polyketide synthase from the plant Aloe arborescens (aloe).
    		 2 Q58VP7 Q58VP7
    Bisdemethoxycurcumin synthase. [EC: 2.3.1.211]
    2 4-coumaroyl-CoA + malonyl-CoA + H(2)O = 3 CoA + bisdemethoxycurcumin + 2 CO(2).
    • A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyzes the formation of the C(6)-C(7)-C(6) diarylheptanoid scaffold of bisdemethoxycurcumin.
    • Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes, the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
    • Formerly EC 2.3.1.n9.
    		 2 Q8LIL0 Q8LIL0